#plasma_protein  any of the proteins in blood plasma
  supertype:  #protein  any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of long chains of polypeptides
  substance of:  #plasm
  subtype:  #human_gamma_globulin__humangammaglobulin__gamma_globulin__gammaglobulin  a plasma protein containing the immunoglobulins that are responsible for immune responses
     subtype:  #immunoglobulin__Ig__immune_serum_globulin__immune_gamma_globulin__immune_globulin  a class of proteins produced in lymph tissue in vertebrates and that function as antibodies in the immune response
        subtype:  #antibody  any of a large variety of immunoglobulins normally present in the body or produced in response to an antigen which it neutralizes, thus producing an immune response
           subtype:  #autoantibody  an antibody acting against tissues of the organism that produces it
              subtype:  #rheumatoid_factor  autoantibody that is usually present in the serum of people with rheumatoid arthritis
           subtype:  #precipitin  an antibody that causes precipitation when it unites with its antigen
           subtype:  #ABO_antibodies  blood type antibodies
           subtype:  #Rh_antibody  rhesus factor antibody
           subtype:  #antitoxin  an antibody that can neutralize a specific toxin
              subtype:  #antivenin__antivenene  an antitoxin that counteracts the effects of venom from the bite of a snake or insect or other animal
              subtype:  #tetanus_antitoxin__tetanusantitoxin  antitoxin given for short-term immunization against tetanus in cases of possible exposure to the tetanus bacillus
           subtype:  #agglutinin  an antibody that causes agglutination of a specific antigen
              subtype:  #isoagglutinin  an antibody produced by one individual that causes agglutination of red blood cells in other individuals of the same species
           subtype:  #heterophil_antibody__heterophile_antibody__heterophileantibody__forssmanantibody  an antibody found in the blood of someone suffering from infectious mononucleosis
           subtype:  #isoantibody__alloantibody  an antibody that occurs naturally against foreign tissues from a person of the same species
           subtype:  #monoclonal_antibody  any of a class of antibodies produced in the laboratory by identical offspring of a hybridoma; very specific for a particular location in the body
           subtype:  #opsonin  an antibody in blood serum that attaches to invading microorganisms and other antigens to make them more susceptible to the action of phagocytes
        subtype:  #immunoglobulin_A__IgA  one of the most common of the five major classes of immunoglobulins; the chief antibody in the membranes of the gastrointestinal and respiratory tracts
        subtype:  #immunoglobulin_D__IgD  one of the five major classes of immunoglobulins; present in blood serum in small amounts
        subtype:  #immunoglobulin_E__IgE  one of the five major classes of immunoglobulins; present primarily in the skin and mucous membranes
           subtype:  #reagin  an immunoglobulin E that is formed as an antibody against allergens (such as pollen); attaches to cell membranes causing the release of histamine and other substances responsible for the local inflammation characteristic of an allergy
        subtype:  #immunoglobulin_G__IgG  one of the five major classes of immunoglobulins; the main antibody defense against bacteria
        subtype:  #immunoglobulin_M__IgM  one of the five major classes of immunoglobulins; involved in fighting blood infections and in triggering production of immunoglobulin G
        subtype:  #tetanus_immunoglobulin__tetanusimmunoglobulin__tetanusimmuneglobulin  sterile solution of globulins derived from the blood plasma of a person who has been immunized for tetanus; provides short-term immunization against tetanus in cases of possible exposure to the tetanus bacillis
  subtype:  #coagulation_factor__coagulationfactor__clottingfactor  any of the factors in the blood whose actions are essential for blood coagulation
     subtype:  #fibrinogen__factor_I  a protein present in blood plasma; converts to fibrin when blood clots
     subtype:  #prothrombin__factorii  a protein in blood plasma that is the inactive precursor of thrombin
     subtype:  #thromboplastin__thrombokinase__factor_III  an enzyme liberated from blood platelets that converts prothrombin into thrombin as blood starts to clot
     subtype:  #calcium_ion__calciumion__factor_IV  ion of calcium; a factor in the clotting of blood
     subtype:  #proaccelerin__prothrombin_accelerator__prothrombinaccelerator__accelerator_factor__acceleratorfactor__factor_V  a coagulation factor
     subtype:  #proconvertin__cothromboplastin__stable_factor__factor_VII  a coagulation factor formed in the kidney under the influence of vitamin K
     subtype:  #antihemophilic_factor__antihaemophilic_factor__antihaemophilicfactor__antihemophilic_globulin__antihaemophilic_globulin__antihaemophilicglobulin__factor_VIII__Hemofil  a coagulation factor (trade name Hemofil) whose absence is associated with hemophilia A
     subtype:  #Christmas_factor__factor_IX  coagulation factor whose absence is associated with hemophilia B
     subtype:  #prothrombinase__factor_X  coagulation factor that is converted to an enzyme that converts prothrombin to thrombin in a reaction that depends on calcium ions and other coagulation factors
     subtype:  #plasma_thromboplastin_antecedent__factor_XI  coagulation factor whose deficiency results in a hemorrhagic tendency
     subtype:  #Hageman_factor__factor_XII  coagulation factor whose deficiency results in prolongation of clotting time of venous blood
     subtype:  #fibrinase__factorxiii  in the clotting of blood thrombin catalyzes factor XIII into its active form (fibrinase) which causes fibrin to form a stable clot

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