#hardening.symptom  abnormal hardening or thickening of tissue
  supertype:  #symptom  (medical) any sensation or change in bodily function that is experienced by a patient and is associated with a particular disease
  subtype:  #callosity__callus  an area of skin that is thick or hard from continual pressure or friction (as the sole of the foot)
     subtype:  #clavus__corn  a hard thickening of the skin (especially on the top or sides of the toes) caused by the pressure of ill-fitting shoes
  subtype:  #calcification.hardening  tissue hardened by deposition of lime salts

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